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Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Plendil. These events are listed in order of decreasing severity within each category, and the relationship of these events to administration of Plendil is uncertain: Body as a Whole: Chest pain, facial edema, flu-like illness; Cardiovascular:Myocardial infarction, hypotension, syncope, anginapectoris, arrhythmia, tachycardia, premature beats; Digestive: Abdominal pain, diarrhea, vomiting, dry mouth, flatulence, acid regurgitation; Endocrine: Gynecomastia; Hematologic:Anemia; Metabolic: ALT (SGPT) increased; Musculoskeletal: Arthralgia, back pain, leg pain, foot pain, muscle cramps, myalgia, arm pain, knee pain, hip pain; Nervous/Psychiatric: Insomnia, depression, anxiety disorders, irritability, nervousness, somnolence, decreased libido; Respiratory: Dyspnea, pharyngitis, bronchitis, influenza, sinusitis, epistaxis, respiratory infection; Skin:Angioedema, contusion, erythema, urticaria, leukocytoclastic vasculitis; SpecialSenses: Visual disturbances; Urogenital: Impotence, urinary frequency, urinary urgency, dysuria, polyuria. Mean peak concentrations following the administration of Plendil are reached in 2. Caution, therefore, should be exercised when using Plendil in patients with heart failure or compromised ventricular function, particularly in combination with a beta blocker. These events are reported from controlled clinical trials with patients who were randomized to a fixed dose of Plendil or titrated from an initial dose of 2. Since blood pressure declines gradually, it may be several weeks before you get the full benefit of Plendil; you must continue taking it even if you are feeling well.

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