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5 times) dose of fluticasone propionate, the addition of SEREVENT Inhalation Aerosol resulted in statistically significantly greater improvements in pulmonary function and asthma symptoms, and statistically significantly greater reductions in supplemental albuterol use. Similar findings were noted in 2 randomized, single-dose, crossover comparisons of Serevent Diskus and SEREVENT Inhalation Aerosol for the prevention of exercise-induced bronchospasm (EIB). Patients receiving Serevent Diskus 50 mcg had significantly greater improvements in 2-hour postdose FEV1 at Endpoint (216 mL, 20%) compared to placebo (43 mL, 5%). Although it is not possible from these reports to determine whether SEREVENTcontributed to these adverse events or simply failed to relieve the deteriorating asthma, the use of Serevent Diskus in this setting is inappropriate. Corticosteroids should not be stopped or reduced when Serevent Diskus is initiated.

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